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  • Components: Ritonavir, Lopinavir
  • Method of action: Antiretroviral Agent
  • Treatment option: Infection, Immunodeficiency

The best analogue of Lopimune is called Kaletra. It has exactly the same composition, pharmacological group, application. You can buy Kaletra or Lopimune in an online pharmacy – just go to the site.

Lately, Lopimune has also been prescribed as a cure for the coronavirus.

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Lopimune helps fight COVID in the latest research.

Possible drugs against the new coronavirus SARS-CoV-2

Lopinavir and ritonavir

A combination of lopinavir and ritonavir, known under the brand name Kaletra/Aluvia, by AbbVie and included in some highly active antiretroviral therapy (HAART) regimens for HIV-1 infection, seems promising.

Lopinavir (lopinavir) is a protease inhibitor (PI) that prevents the synthesis of viral proteins and thereby leads to the formation of an immature and incapable of infection virus. Ritonavir (ritonavir) also belongs to the PI class, but is not used on its own, finding use as a booster (amplifier) ​​of other PIs: it inhibits cytochrome P450 3A4 (CYP3A4), a liver enzyme that metabolizes xenobiotics, that is, it deactivates drugs.

Buy Lopimune online – lopinavir and ritonavir

Thus, the administration of lopinavir and ritonavir together with ribavirin, which induces hypermutations in the mechanism of RNA replication, to patients with SARS-CoV infection was reflected in a milder course of the disease, both in terms of adverse clinical outcomes (ARDS and death) and positions of cases of diarrhea, recurrence of a feverish state and deterioration of results of a roentgenography of a thorax; demonstrated an enhanced reduction in viral load.

Phase II/III MIRACLE (NCT02845843) clinical trials are ongoing, testing the combination of lopinavir, ritonavir, and interferon beta-1b for MERS-CoV infection. The hypothesis of the researchers is based on the effectiveness of the combination in vitro, in animal experiments and a number of successful cases of its application in practical conditions on patients.

The potential of lopinavir was witnessed by the German Innophore, which focused on structural enzymology and turned to the facts of a “fairly successful” cure of Chinese SARS-CoV patients with protease inhibitors. Since the main protease (Mpro), also known as chymotrypsin-like protease (3CLpro), is highly conserved in coronaviruses, and in the case of SARS-CoV-2, it is 96% homologous to that of SARS-CoV, it is quite possible to use drugs against the new coronavirus infection COVID-19 this class. Innofor, which carried out computer screening of the SARS-CoV-2 genome, identified its protease and determined that lopinavir is the most appropriate inhibitor in this case.

Lopimune tablets India – buy lopinavir and ritonavir online

Three Chinese hospitals reportedly started using a combination of lopinavir and ritonavir (twice daily at 400 and 100 mg, respectively) along with intranasal interferon alfa-2b. The outcomes of therapy are not yet fully known, but there are many cases of complete cure. Along the way, the corresponding clinical trials of ChiCTR2000029308 (randomized, open) were organized.

AbbVee promised to organize the supply of Kaletra/Aluvia worth 10 million yuan ($1.44 million). In the meantime, Lopimune is prescribed – a generic copy of Kaletra / Aluvia by the Indian Cipla. And the problem is not in the cost – for 60 tablets, the pharmaceutical company asks for 2 thousand rupees ($ 28), but in stocks: before the outbreak of the new coronavirus SARS-CoV-2, the demand for the drug was not so strong as to accumulate raw materials in abundance for it. production. Currently, Cipla can produce 10-12 million tablets. However, there are other generic manufacturers in India as well.

It should be understood that at the moment it is categorically unclear whether protease inhibitors are truly effective in the treatment of SARS from Wuhan. It is possible that the biologically active level of lopinavir with ritonavir will not in all cases be sufficient for a strong antiviral effect against the SARS-CoV-2 coronavirus. The bottom line is that almost all protease inhibitors are literally completely bound to plasma proteins, leaving only a tiny fraction for their unbound form, which has therapeutic effects. The high activity of protease inhibitors in the case of HIV is explained by the fact that the virus is extremely sensitive even to their insignificant free concentrations.